from Fireplaces, Gives you a familiar which is a smaller version of the Plum boss, which sprays tears and propels itself around the room, Deals 2 contact damage per tick to enemies, and the tears deal 3 damage each, Deals contact damage to any enemies it runs into, UNLOCK: Unlock this item by beating Baby Plum 10 times, When used, this item calls a friendly version of the Plum boss to fight for you for 10 seconds, It will jump to the nearest enemy, slam on the ground and fire tears around it, then propel itself around the room, dealing contact damage to any enemies it touches before disappearing, It's possible to get a guaranteed spawn of this item by encountering the Baby Plum boss and not damaging her. If you have PhD it will only increase one stat, Can be used multiple times, but every time you use it, it has a chance to disappear, The Gold Pill can spawn as a Horse Pill, which then causes it to give random Horse pill effects, UNLOCK: Unlock this by defeating Mega Satan as Tainted Cain, Horse Pills rarely spawn as larger versions of normal pills with more powerful effects, Items that synergize with pills also have the same effect with Horse pills, In general, the effect of a Horse Pill is double the effect of a normal pill i.e. pants, under wear, pink, knickers, moms underwear, mom underwear, REPENTANCE - Touching enemies deals 12 damage to them, Item Pool: Boss Room, Challenge Room, Mom's Chest, * dungeon room, blood challenge room, arena pool, boss room pool, boss room item, red, high, shoe, moms heels, mom heels, Drops a random heart on the floor when picked up, * moms lipstick, mom lipstick, dungeon room, blood challenge room, arena pool, boss room pool, boss room item, red, grey, gray, UNLOCK: Unlock this item by beating Mom's Heart 4 times, Gives Isaac angel wings for the current room, allowing him to fly, Instantly kills the Mom's Foot, Mom's Heart and It Lives boss fights, If used during the Satan fight, The Bible will instantly kill Isaac, Counts as 1 of 3 angel items needed towards the Seraphim transformation, REPENTANCE - Reduced to 4 room recharge time, * library pool, library room, book room pool, angel room pool, god room pool, angel room item, Half hearts heal a whole heart and full hearts heal 2 red hearts, UNLOCK: Unlock this item by beating Boss Rush with Maggy, * item room, treasure room, item room pool, the lost item pool, pink, purple, candy, Each time you enter a new room, damage is negated for the first time you get hit, Can be used to go in and out of a Curse Room without taking damage. Haemolacria tear appearance with Brimstone. Isaac was a son, husband, father, brother and grandfather. This means you can leave rooms before defeating the enemies inside, Doesn't open locked doors, or the door that leads to the Boss Room, Heals one red heart container when picked up, This item causes nearby enemies to be affected by the charm effect, causing them to attack other nearby enemies, The charm effect will wear off very quicky when enemies move away from Isaac, This item causes your tears to become rocks, which have increased knockback and can break other rocks and objects. Tears down: Delay * 3. Recharge time: Starts at 1 second, increasing by every time you use it. 's unique poops, Corn poop - Spawns a blue fly every 2 seconds, Flaming poop - Leaves behind fire that damages enemies, Black poop - Creates slowing black creep. This will deviate you from the alt path if you are currently on it, Since this item resets your stats, this item can remove Broken Hearts, UNLOCK: Unlock this item by defeating Greedier Mode as Jacob & Esau, Item Pool: Angel Room, Greed Mode Angel Room, Upon use, allows you to consume 1 key and fire it at an enemy, piercing enemies and dealing significant damage, The damage done by the key projectile pierces through enemies and scales with your damage upgrades (x5 damage + 30), Keys fired by this item can open locked doors/chests, secret rooms and destroy objects in the room, such as rocks, Cannot be used if you don't have any keys, Enemies killed by Sharp Key have a ~10% chance to spawn random items that appear in a chests. Magic Fingers ignores the +40 flat damage with Ipecac, removing the synergy between these two, * shop room pool, shop item pool, item room, treasure room, item room pool, tissue, with Brimstone you get 4 lasers, Counts as 1 of 3 spider items needed towards the Spider Baby transformation, * item room, treasure room, item room pool, green, black, +2 Damage Up for tears fired from Isaac's left eye, If playing as Cain or you have an item which modifies which eye you fire tears from, each shot has a 50% chance to do +2 Damage, * item room, treasure room, item room pool, poison, green, brown, bottle, jar, danger, Gives Isaac an eye companion that floats around the room and deals 8 damage per tick on contact with enemies, Damage from Isaac's left eye deal roughly +35% damage, * item room, treasure room, item room pool, red, white, When you take damage, this item recharges one room's worth of charge to your spacebar item, For example, with the D6 you would need to take damage 6 times to fully recharge it, * angel room pool, god room pool, angel room item, shop room pool, shop item pool, Isaac's touch now petrifies enemies, turning them to gold for a few seconds. ?, Satan and The Lamb as Tainted Lost. Blood Of The Martyr Damage Up. Holding this trinket increase that chance by +15%. white, square, When used, you have a chance of getting one of the three following effects: Treasure Map (floor layout), Compass (map icons) or Blue Map (secret room locations), REPENTANCE - Book of Secrets now avoids giving mapping effects that the player already has. Trinkets grey, gray, Gives the player an invulnerability effect which lasts for a 10 seconds, Can be used to get free hits on the Blood Donation machines and Devil Beggars, * library pool, library room, book room pool, item room, treasure room, item room pool, white, pink, Allows Isaac to walk over gaps with a width of one tile, * shop room pool, shop item pool, the lost item pool, brown, wooden, Heals half a heart after every 13 enemies killed, Works with the Keeper for restoring coin HP, * item room, treasure room, item room pool, the lost item pool, black, grey, gray, bat, All spacebar items can now be 'overcharged', allowing them to be charged up twice instead of once, The extra charges appear in yellow on top of the normal green bars, This item works with self-recharging items, * shop room pool, shop item pool, pink, purple, 15c items are reduced to 7c. A familiar that follows Isaac and charges forwards very slowly, dealing 2.7 damage per tick to any enemies it comes into contact with, Almost identical to the Little Chubby familiar, but this one moves much more slowly and deals less damage, REPENTANCE - The damage tick rate on Big Chubby has been increased, Upon use, this item deals 9,999,999 damage to all enemies in the room and then kills you 3 seconds later, This is a single use active item, meaning it is destroyed after using it, Does not kill both phases of multi-phase bosses like Hush or Ultra Greed, If used to kill a boss, the kill still counts as a victory for post-it note completion marks, but the run will still get a game over, Delirium's death animation takes longer than 3 seconds, meaning you will die before it can count as a completion mark. Certain items consider Quality for picking what item to spawn, allowing better items to spawn under certain conditions, UNLOCK: Unlock this item by defeating The Beast as Tainted Lost, Spawns a special set of spikes in the Devil Room, Taking damage from the spikes has a chance to spawn a reward, UNLOCK: Unlock this item by defeating The Beast as Tainted Judas, When picked up, this gives you 9 orbital flies, Each time a fly blocks an enemy shot, it will turn into a blue fly and attack nearby enemies, leaving you with one less orbital, Every room clear gives you +1 orbital fly, up to a maximum of 9, UNLOCK: Unlock this item by defeating The Beast as Tainted Blue Baby, Gives you +0.25 Damage Up for every broken heart you have, Every hit of damage that would kill you, instead adds 2 more broken hearts and deal 40 damage to all enemies in the room, UNLOCK: Unlock this item by defeating The Beast as Tainted Eve, Every time you take damage, you gain a Speed Up and a Tears Up, The stat increases start small, and scale up each time you take damage (+0.25 Tears Up for the first hit, +0.75 Tears Up for the 6th hit), The effect maxes out at +3 Tears Up and +1 Speed Up after taking damage 6 times. Rotten Meat = +1 flat damage, +1.5 range. REPENTANCE - +0.2 Speed Up (Used to be -0.1 Speed before Repentance). Share your thoughts, experiences, and stories behind the art. UNLOCK: Unlock this item by defeating challenge #36 (Scat Man), When used, places a sword directly above Isaac's head and while active, will spawn an extra item for every item pedestal spawned, After getting hit once with the item activated, at any time without warning, the sword may fall, instantly killing Isaac regardless of his health, After being hit the sword has a 1/10000 chance every 4 frames to fall. The floor generation can fail and cause the guaranteed Planetarium to not spawn sometimes. Can only be accessed via the Red Key, Crystal Key or Cracked Key. Brimstone is a passive item. grey, gray, blue, moms eyeshadow, Tears now have a chance to concuss enemies, causing them to walk around dazed and confused for a short period of time, The chance to concuss enemies is affected by your luck stat and at +27 Luck it will activate every time, * item room, treasure room, item room pool, grey, gray, silver, ingot. Effects Using the Red Key near it will spawn a red room, This room will randomly choose from many types, including (but not limited to) any regular room from that floor, treasure rooms, curse rooms, devil rooms, angel rooms, I AM ERROR rooms and more, In rooms with multiple door outlines, the closest one will be opened, Attempting to create a room outside the maximum boundary (13 x 13 rooms) of the map will take you to an I AM ERROR room. Those tears will cause the same effect if they happen to hit other enemies, Effects that replace your tears such as Brimstone simply have a chance to apply this effect, Any enemies that come within close range of Isaac will become feared, which causes them to flee, When used, this item takes away 5 of your coins and gives a +1.2 Damage Up that lasts for the current room, Can stack as many times as you want. This tear turns enemies to gold for a few seconds and causes them to drop 1-4 coins if killed while golden (similar to the Midas' Touch item), When the Midas Touch tear effect triggers, it will remove 1 coin from your current total, The golden tear deals double your tear damage, The effect can still trigger even if you have no held coins, UNLOCK: Unlock this item by defeating Greedier Mode with Keeper, Doubles the effect of most tarot cards. Pickup Quote shop room pool, shop item pool, cross, brown, Upon use, gives +2 damage up which lasts for the current room, x1.5 times Damage Multiplier if you also have Blood of the Martyr (Does not stack with Magic Mushroom or Cricket's Head multipliers), Increases your chances of getting a devil/angel room by +12.5%, REPENTANCE - The effect stacks if used multiple times, * library pool, library room, book room pool, devil pool, devil room pool, devil deal, starting Objects Counts as 1 of 3 angel items needed towards the Seraphim transformation. Blood Clot: All tears are larger, with increased damage (as opposed to every 2nd tear like Blood Clot alone). in shops or devil rooms), The only way to survive the falling sword is either through extra lives, by using items that would make you invincible, such as Gnawed Leaf or playing as The Lost. Effect persists between rooms while the time period is active, Speed Down - Reduces your speed stat by -0.12, Speed Up - Increases your speed stat by +0.15, Tears Down - Reduces your tears stat by -0.28, Tears Up - Increases your tears stat by 0.35, Telepills - Teleports you to a random room when used. The more you spend the higher the stat increase, Possible stats include Speed, Damage and Range, 15c items give all 3 stats: +1 Damage Up, +0.03 or +0.06 Speed Up, +0.25 or +0.5 Range Up, 5c items give 1 or 2 stats: +0.5 Damage Up **OR** +0.25 Range and +0.03 Speed Up, UNLOCK: Unlock this item by defeating Mother as The Keeper, While in a room with enemies, blue spiders will randomly spawn from objects in the room (e.g. You get a couple of seconds of invincibility to move away after, The main benefit of this Soul Stone is that it automatically activates if you die, meaning it is effectively an extra passive life while held, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Lazarus, Activates the D6 and D20 effects, rerolling all items and pickups in the room. The only way to remove broken hearts is by donating to a Confessional Machine, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Jacob & Esau, Holding the fire button charges up a light beam attack similar to Brimstone, The light beam deals damage equal to your current tear damage per tick to any enemies touching it, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Bethany, When picked up, this item gives you a stat increase, based on which is currently the lowest. ( : IPECAC Tough Love Technology 2 Mutant Spider Epic Fetus Polyphemus Sacred Heart), Stat Ups: The Sad Onion Max's Head Number One Blood of the Martyr Magic Mushroom Roid Rage Raw Liver Lunch Dinner Dessert Breakfast Rotten Meat Wooden Spoon The Belt Mom's Underwear Mom's Heels Mom's Lipstick Wire Coat Hanger Steven Pentagram The Mark Growth Hormones Mini Mushroom The Pact Small Rock Super Bandage Robo-Baby Little C.H.A.D. grey, gray, pentagram, Deals 40 damage to everything in the room when used, REPENTANCE - Reduced to 3 room recharge time, UNLOCK: Unlock this item by using 4 XIII - Death cards, Item Pool: Library, Secret Room, Devil Room, * library pool, library room, book room pool, secret room pool, devil pool, devil room pool, Most items that change tear color will also give Brimstone an exotic appearance, but they do not combine and only one color effect is shown. red, bolt, cupid arrow, cupids arrow, When used, fires a high damage laser in a straight line across the room in a similar way to Brimstone, The laser deals damage equal to double your tear damage. After killing a 25 more enemies, it transforms again dealing 15 damage and destroying obstacles it charges into. Isaac Hanson joined legislators and health officials . the lost item pool, purple, cross, Item Pool: Curse Room, Devil Room, Demon Beggar, * curse room pool, devil pool, devil room pool, devil deal, red, 666, Item Pool: Devil Room, Curse Room, Demon Beggar, * curse room pool, devil pool, devil room pool, devil deal, piece of paper, bloody paper, contract, Pickups Spoon Bender will give them a homing effect, and status effects like fear/poison will spread onto all enemies the electricity chains to, Tears which fall naturally to the floor at max range do not generate sparks, It's possible to fire tears at a wall to create electricity that damages enemies on the other side of the wall, *, silver, metal, grey, gray, blue, jacob ladder, jacobs ladder, Each tear now has a small chance to be a spectral blue flame instead, which deals damage to enemies that come in contact with it, The fire will remain in place and shrink in size when deals damage to something. Based on the Steam Workshop mod created by Amethyst, UNLOCK: Unlock this item by using 5 Gulp! If you have 40 bombs it will spawn 4 x Boom! The longer the button is held the faster Gurdy will fling itself across the screen, Deals a fixed amount of damage depending on charge level, at lowest being ~5 and at max being ~20, Lil Gurdy bounces off of enemies and obstacles, A beggar head which floats around the room and picks up any nearby coins. soul or black hearts, Your devil deal chance isn't ruined by this item taking away red hearts. The chemical signals travel through your blood to the spleen, where many platelets are stored. Confuses all enemies briefly when destroyed, White poop - Same effect as Hallowed Ground, Stone poop - Deals extra thrown damage, can hit multiple enemies. Pretty Fly gives a Big Fan item rather than a fly orbital, UNLOCK: Unlock this by defeating Mega Satan as Tainted Eve, 1 Dot - Rerolls all of your items. They also no longer block player attacks or get extinguished by them, UNLOCK: Unlock this item by donating 400 pennies to the Shop, Isaac can now pick up hearts while at full health, which will be stored in the Jar and can be spawned again using the spacebar, Soul hearts and black hearts cannot be stored, If used in a Black heart or Eternal heart super secret room, it will spawn the relevant heart, * shop room pool, shop item pool, the lost item pool, glass. If you have 1 or less heart containers, this pill becomes Health Up, Hematemesis - Empties all but one red heart container and spawns 1-4 red hearts on the floor. Tainted Eve is unlocked by reaching Home and using the Red Key, Cracked Key, or Soul of Cain to access a special room in one of the walls while playing as Eve. Kicking a frozen enemy will push it into the wall, where it shatters and fires ice shards everywhere (these can then freeze other enemies), Enemies touching the cube while it's not moving or moving slowly will become slowed for a few seconds, and take a small amount of damage, Cube Baby and enemies frozen will block enemy shots, Cube Baby can be launched across the room if you have a melee weapon, Enemies that die now spawn a red ghost, that floats in place of where the enemy died, Activating the item causes all red ghosts in the room to explode, dealing damage to any enemies near them, The explosion doesn't deal damage to Isaac, Damage dealt by each ghost is 3 + 0.04x the HP of the enemy it spawned from, Larger enemies such as minibosses will spawn a larger red ghost that causes 3 explosions, The red ghosts can be moved around slightly by firing tears through them, Using the item will instantly kill any enemy or boss that has the 'ghost' tag and is at 50% or less HP. e.g. Curses This can make it confusing while navigating the room, Dataminer will randomly increase or decrease one of your stats by a small amount when used, Gives you the Fruit Cake effect for the room when used, which will give a random tear effect with every tear fired, All visual and tear effects reset after leaving the room, * data miner, red, pickaxe, minecraft, pixel, When used, this item will randomly change you into another character and remove the last item you picked up, All stat changes of the new character are applied (e.g. Floor generation can fail and cause the guaranteed Planetarium to not spawn sometimes guaranteed! +1 flat damage, +1.5 range recharge time: Starts at 1,! 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