Swine: LUTALYSE Sterile Solution will induce parturition in swine at 10 mg (2 mL) when injected intramuscularly. This can be employed to control the time of farrowing in sows and gilts in late gestation. 2. Inject 5 mL LUTALYSE Injection (equivalent to 5 mg/mL dinoprost) 1 day prior to EAZIBREED CIDR Cattle Insert removal, on Day 6 of the 7 day administration period. For estrus synchronization in beef cows, beef heifers and replacement dairy heifers, For unobserved (silent) estrus in lactating dairy cows with a corpus luteum, For treatment of pyometra (chronic endometritis) in cattle, For abortion in beef cows, beef heifers and replacement dairy heifers, For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows, For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in lactating dairy cows, For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers, For controlling the timing of estrus in estrous cycling mares, For difficult-to-breed mares (clinically anestrous mares that have a corpus luteum). Managers using prostaglandins in this manner must use caution. 2 mL (10 mg). These effects are usually seen within 15 minutes of injection and disappear within one hour. The 30mL bottle may be used for cattle, swine, or mares. Mares should not be treated if they suffer from either acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system, or reproductive tract. 5. Revised: September 2021 Induction of abortion in feedlot cattle at stages of gestation up to 100 days of gestation did not result in dystocia, retained placenta or death of heifers in the field studies. User Safety: Not for human use. Some of these factors are: a. On Day 5, cows are given a shot of prostaglandin (PGF 2 ) which synchronizes a majority of the cows to be in heat/estrus from Day 6 through Day 10. Necessary cookies are absolutely essential for the website to function properly. 2018 Pipestone Veterinary Services. First, Lutalyse is a brand name of the drug dinoprost tromethamine, which is a synthetic prostaglandin. There was no evidence of toxicological effects. Sweating was temporary in all cases and was mild for doses of 3.0 mg or less but was extensive (beads of sweat over the entire body and dripping) for the 10 mg dose. The normal duration of estrus cycle is 21 days in cow, sow, and mare, 17 days in ewe, and 20 days in doe. For Treatment of Pyometra (chronic endometritis) in Cattle: In studies conducted with LUTALYSE Injection, pyometra was defined as presence of a corpus luteum in the ovary and uterine horns containing fluid but not a conceptus based on palpation per rectum. Many mares described as anestrus during the breeding season have serum progesterone levels consistent with the presence of a functional corpus luteum. DESCRIPTION LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Mares: 1. Sweating was temporary in all cases and was mild for doses of 3.0 mg or less but was extensive (beads of sweat over the entire body and dripping) for the 10 mg dose. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchiospasms. Dinoprost tromethamine is a white or slightly off-white crystalline powder that is readily soluble in water at room temperature in concentrations to at least 200 mg/mL. On Day 5 inject all cows not bred. Indicated for estrus synchronization with Factrel, and treatment of pyometra in cattle and for parturition induction in swine. Swine: The most frequently observed side effects were erythema and pruritus, slight incoordination, nesting behavior, itching, urination, defecation, abdominal muscle spasms, tail movements, hyperpnea or dyspnea, increased vocalization, salivation, and at the 100 mg (10x) dose only, possible vomiting. Different breeds are different as far as when you'd want to induce them. Lutalyse for goats can be effective in changing phase length and well as addressing "cystic" does and has been shown to help some does "reset" hormonally and resolve some fertility issues. For Unobserved (Silent) Estrus in Lactating Dairy Cows with a Corpus Luteum. Prostaglandins have been reported to result in release of pituitary tropic hormones. Both Lutalyse and Estrumate (and the generic equivalents) can be used to successfully induce labor in pregnant sows and gilts. The sow should stop eating, drop her udder, lay down and begin having abdominal contractions. Between 5 and 35 days post-service an administration of a single dose of Lutalyse has been successfully used to terminate pregnancy. Refer to extra-label drug use. Lutalyse Injection (dinoprost injection) 5 mg dinoprost/mL as dinoprost tromethamine Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Data suggest prostaglandins, especially PGEs and PGFs, may be involved in the process of ovulation and gamete transport. After day 114 of gestation prostaglandin F2 alpha may be used to induce farrowing. Cattle: LUTALYSE Injection is indicated as a luteolytic agent. one of the most widely use d natural polysaccharides in the food, agriculture, textile, pol-. For Treatment of Pyometra (chronic endometritis) in Cattle. These cookies do not store any personal information. Sweating after the 5.0 mg dose was intermediate between that seen for mares treated with 3.0 and 10.0 mg. Sweating began within 15 minutes after injection and ceased by 45 to 60 minutes after injection. For Parturition Induction in Swine: For intramuscular use for parturition induction in swine. Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection. LUTALYSE Injection can be used to induce parturition in swine if administered within three days of the normal expected farrowing. Physical exposure using an intact or vasectomized boar provides the full range of stimuli. A 14-day continuous intravenous infusion study in rats at 20 mg PGF2 per kg body weight indicated prostaglandins of the F series could induce bone deposition. The smallness of the fetus at this early stage of gestation should not lead to complications at abortion. A study demonstrated that equimolar doses of 3H PGF2 alpha Tham and 3H PGF2 alpha free acid administered intravenously to rats demonstrated no significant differences in blood concentration of dinoprost. Dinoprost is a natural prostaglandin. Use only sterile needles, and use each needle only once. Among them . With the two injections cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE Injection. Of those mares bred, 59% were pregnant following an average of 1.4 services during that estrus. 4.2 Indications for use, specifying the target species Lutalyse is indicated for its luteolytic and/or oxytocic effects in cattle, horses and pigs. For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: For a full description of the studies conducted for the use of FACTREL Injection and LUTALYSE Injection, please refer to the labeling for FACTREL Injection. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are as essential for the working of basic functionalities of the website. Cattle: LUTALYSE Sterile Solution is supplied at a concentration of 5 mg dinoprost per mL. Estrus may be induced in diestrous mares (having a corpus luteum that is 5 or more days postovulation) by treatment with natural PGF 2 (10 mg, IM) or cloprostenol (250 mcg, IM) to lyse the corpus luteum. Lutalyse is used as an injectable luteolytic for the synchronization of estrus in swine and cattle to reduce labor costs and increase efficiency in reproduction. Aggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse. This luteolytic action may be utilized to: Effectively control the time of estrus in cycling cattle that have a corpus luteum Treat sub-estrus (no visible estrus) Induce abortion in cattle from 5 to 130 days of gestation Treat chronic metritis and pyometra The indications for use are: Cattle 1. Do not administer intravenously (IV) as this route may potentiate adverse reactions. The metabolism of tritium labeled dinoprost (3H PGF2 alpha) in the rat and in the monkey was similar. 3. LUTALYSE HighCon Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 5mL LUTALYSE Injection (25 mg dinoprost) intramuscularly. Lutalyse Injectable is used in cattle for estrus synchronization, treatment of uterine infections, and induction of abortion; in swine for induction of parturition and in horses f Route of administration for each dose group was both intramuscularly (2 mares) and subcutaneously (2 mares). Cattle expressing estrus following LUTALYSE Injection are receptive to breeding by a bull. For Abortion in Beef Cows, Beef Heifers and Replacement Dairy Heifers. JavaScript seems to be disabled in your browser. In pigs, evaluation was made of clinical observations, food consumption, clinical pathologic determinations, body weight changes, urinalysis, organ weights, and gross and microscopic observations following treatment with single doses of 10, 30, 50 and 100 mg dinoprost administered intramuscularly. Controlling Time of Estrus of Estrous Cycling Mares: Mares treated with LUTALYSE Injection during diestrus (4 or more days after ovulation) will return to estrus within 2 to 4days in most cases and ovulate 8 to 12 days after treatment. Difficult-to-Breed Mares: In extended diestrus there is failure to exhibit regular estrous cycles which is different from true anestrus. Lutalyse is used to control the timing of estrus and ovulation in estrous cycling cattle that. Of those mares bred, 59% were pregnant following an average of 1.4 services during that estrus. Rectal temperature was decreased during the interval 0.5 until 1.0, 3 to 4, or 5 hours after injection for 0.25 and 1.0 mg, 2.5 and 3.0, or 5.0 and 10.0 mg dose groups, respectively. For Intramuscular Use for Treatment of Pyometra (chronic endometritis) in Cattle. All Rights Reserved. Residue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. LUTALYSE Injection (5 mg dinoprost/mL) is a sterile solution containing the naturally occurring prostaglandin F2 alpha (dinoprost) as the tromethamine salt. Other measurements evaluated in the study remained within normal limits. To exhibit using lutalyse to induce heat in swine estrous cycles which is different from true anestrus HighCon Injection indicated! Cows, Beef Heifers and Replacement Dairy Heifers and ovulation in estrous cycling cattle that a! 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